Making the decision to start a weight loss medication is an exciting first step towards meeting your goals and feeling like your best self. What happens when that medicine comes with some potential side effects and you aren’t quite feeling like your best self along the way?Â

GLP-1 medications, like Semaglutide (known as Ozempic or Wegovy) and Tirzepatide (Mounjaro) are also being used for weight management because of their ability to regulate appetite and glucose levels. While they can be incredibly effective they may also cause some side effects. Let’s explore the most common side effects and tips on how to manage them!
1. Nausea
One of the most frequently reported side effects of GLP-1 medications is nausea, especially when first starting the treatment or increasing the dose. These medications slow down how fast food leaves the stomach, which can cause a feeling of fullness and discomfort. We can also feel less hungry, leaving our stomach empty for longer periods of time, which can also cause nausea.
How to manage nausea:
Start slow: Start on a lower dose and gradually increase to minimize discomfort.
Eat smaller meals: Eat smaller, more frequent meals throughout the day and include protein rich snacks.
Avoid greasy foods: Fatty or fried foods can trigger nausea, so sticking to lighter, easily digestible meals may help.
Stay hydrated: Sipping on water or herbal teas can help settle your stomach and keep you hydrated. Peppermint is commonly used for upset stomach.
2. Vomiting
In some cases, nausea can lead to vomiting, particularly during the early stages of treatment. While this side effect can be uncomfortable, it often subsides as your body adjusts to the medication.
How to manage vomiting:
Talk to your healthcare provider: They may recommend an anti-nausea medication to help you through the adjustment period.
Listen to your body: If you feel too full or uncomfortable, take a break from eating and rest until you feel better.
Stick to bland foods: Foods like crackers, toast, and bananas can help ease an upset stomach.
3. Diarrhea
Some individuals may experience diarrhea as their digestive system adjusts to the medication. This can be inconvenient but usually improves with time.
How to manage diarrhea:
Stay hydrated: Make sure to drink water, broth, or electrolyte drinks to replace any fluids lost.
Avoid trigger foods: High-fat, spicy, or sugary foods can make diarrhea worse, so it's best to avoid them temporarily.
Eat fiber-rich foods: Foods like oatmeal, applesauce, and bananas may help firm up stools and alleviate symptoms.
Over the counter medications like Pepto Bismol can help as well.
4. Constipation
While some people experience diarrhea, others may find they have the opposite issue—constipation. This is because GLP-1 medications slow digestion, which can lead to less frequent bowel movements.
How to manage constipation:
Increase fiber intake: Eating more fruits, vegetables, and whole grains can help get things moving.
Stay active: Light exercise, such as walking, can stimulate your digestive system.
Drink plenty of water: Proper hydration can help soften stools, making them easier to pass.
Take a daily probiotic to keep the good bacteria working.Â
5. Fatigue
Some people report feeling more tired or sluggish while taking GLP-1 medications. This may be due to the changes in blood sugar regulation or the body adjusting to the medication.
How to manage fatigue:
Get enough sleep: Prioritize rest to help your body adjust to the new treatment.
Eat balanced meals: Make sure you're consuming enough nutrients and energy to support your daily activities.
Incorporate B12 injections for a natural energy boost
Talk to your healthcare provider: If fatigue persists, it’s important to rule out other underlying causes.
6. Decreased Appetite
A hallmark of GLP-1 medications is that they suppress appetite, which can be beneficial for weight loss but may also lead to a lack of interest in food.
How to manage decreased appetite:
Eat nutrient-dense foods: Focus on quality over quantity by eating small portions of nutrient-rich foods like lean proteins, healthy fats, and vegetables.
Don’t skip meals: Even if you’re not hungry, it’s important to maintain regular meals to keep your energy levels up.
Incorporate protein shakes into your day. Protein is incredibly important to maintain muscle when in a caloric deficit.Â
When to Talk to Your Healthcare Provider
While most side effects are manageable and tend to improve with time, it’s essential to keep in touch with your healthcare provider if any symptoms are severe or persistent. They can adjust your dosage, offer additional advice, or suggest medications to help manage side effects.
Final Thoughts
GLP-1 medications like Semaglutide and Tirzepatide can offer incredible benefits, especially for those looking to manage diabetes or lose weight. Understanding the common side effects and how to manage them can help ensure a smoother treatment journey. Always communicate with your healthcare team about any concerns or side effects to get the most out of your medication.
By being informed and proactive, you can take control of your health and wellness while reaping the benefits of these powerful medications.
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